The landscape of host genetic factors involved in immune response to common viral infections.

ABSTRACT:

Background

Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response to viral infection provides insight into disease etiology and therapeutic opportunities.

Methods

We conducted a comprehensive study including genome-wide and transcriptome-wide association analyses to identify genetic loci associated with immunoglobulin G antibody response to 28 antigens for 16 viruses using serological data from 7924 European ancestry participants in the UK Biobank cohort.

Results

Signals in human leukocyte antigen (HLA) class II region dominated the landscape of viral antibody response, with 40 independent loci and 14 independent classical alleles, 7 of which exhibited pleiotropic effec

SUBMITTER: Kachuri L 

PROVIDER: S-EPMC7590248 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature