Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium.

ABSTRACT:

Background

Viral respiratory tract infections, such as influenza A virus (IAV), are common and life-threatening illnesses worldwide. The mechanisms by which viruses are removed from the respiratory tract are indispensable for airway host defense. Mucociliary clearance is an airway defense mechanism that removes pathogens from the respiratory tract. The coordination and modulation of the ciliary beating of airway epithelial cells play key roles in maintaining effective mucociliary clearance. However, the impact of respiratory virus infection on ciliary activity and mucociliary clearance remains unclear.

Methods

Tracheal samples were taken from wild-type (WT) and Toll-like receptor 3 (TLR3)-knockout (KO) mice. Transient organ culture of murine trachea was performed in the pres

SUBMITTER: Kamiya Y 

PROVIDER: S-EPMC7590254 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature