Complement deposition, C4d, on platelets is associated with vascular events in systemic lupus erythematosus.

ABSTRACT: OBJECTIVE:Complement components, including C4d, can be found on activated platelets, a process associated with vascular disease in SLE. We investigated whether platelet C4d (PC4d) adds additional value to traditional and known lupus-associated risk factors when identifying SLE patients with vascular disease. METHODS:This cross-sectional study included 308 well-characterized SLE patients and 308 matched general population controls. PC4d deposition was analysed using flow cytometry. Values >95% of controls were considered as PC4d positive (+). aPL were determined by Luminex, and the LA test was performed by DRVVT. History of vascular disease (composite and as separate outcomes) was defined at inclusion. RESULTS:SLE patients had increased PC4d deposition as compared with population controls (50 vs 5%, P?

SUBMITTER: Svenungsson E 

PROVIDER: S-EPMC7590416 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature