Circulating plasma metabolites and risk of rheumatoid arthritis in the Nurses' Health Study.

ABSTRACT:

Objectives

RA develops slowly over years. We tested for metabolic changes prior to RA onset using a large non-targeted metabolomics platform to identify novel pathways and advance understanding of RA development.

Methods

Two hundred and fifty-four incident RA cases with plasma samples drawn pre-RA onset in the Nurses' Health Study (NHS) cohorts were matched 1:2 to 501 controls on age, race, menopause/post-menopausal hormone use and blood collection features. Relative abundances of 360 unique, known metabolites were measured. Conditional logistic regression analyses assessed associations between metabolites and incidence of RA, adjusted for age, smoking and BMI, accounting for multiple comparisons. Subgroup analyses investigated seropositive (sero+) RA and RA within 5 years o

SUBMITTER: Chu SH 

PROVIDER: S-EPMC7590418 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature