Serum sTREM-1 in adult-onset Still's disease: a novel biomarker of disease activity and a potential predictor of the chronic course.

ABSTRACT:

Objectives

Triggering receptor expressed on myeloid cells-1 (TREM-1) is an amplifier of inflammatory signals. Recently, a soluble form of TREM-1 (sTREM-1) was described. This study aimed to investigate the role of serum sTREM-1 in patients with adult-onset Still's disease (AOSD).

Methods

Serum sTREM-1 levels were detected in 108 AOSD patients, 88 RA patients and 112 healthy controls (HC). The correlations of sTREM-1 with disease activity, clinical characteristics and laboratory parameters in AOSD patients were analysed by the Spearman correlation test. Risk factors for the chronic course of AOSD were evaluated by multivariate logistic regression analysis.

Results

AOSD patients had significantly higher serum sTREM-1 levels than RA patients and HC, and serum sTREM-1 lev

SUBMITTER: Wang Z 

PROVIDER: S-EPMC7590420 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature