Effect of body mass index on response to neo-adjuvant therapy in HER2-positive breast cancer: an exploratory analysis of the NeoALTTO trial.

ABSTRACT:

Background

Obesity is a risk factor for breast cancer (BC) development, recurrence, and death. In view of this, we aimed to investigate the clinical value of obesity in BC patients treated with anti-HER2 therapies in the NeoALTTO trial, which randomized 455 patients to neo-adjuvant lapatinib, trastuzumab, or their combination plus paclitaxel.

Methods

Patients were classified according to their basal body mass index (BMI) into underweight (< 18.5 kg/m²), normal (≥ 18.5; < 25 kg/m²), overweight (≥ 25; < 30 kg/m²), and obese (≥ 30 kg/m²) WHO categories. Univariate and multivariate logistic regression analyses were performed using BMI as a categorical variable. Pathological complete response (pCR) and event-free survival (EFS) were the

SUBMITTER: Di Cosimo S 

PROVIDER: S-EPMC7590445 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature