Application of SWATH mass spectrometry in the identification of circulating proteins does not predict future weight gain in early psychosis.

ABSTRACT: Weight gain is a common consequence of treatment with antipsychotic drugs in early psychosis, leading to further morbidity and poor treatment adherence. Identifying tools that can predict weight change in early psychosis may contribute to better-individualised treatment and adherence. Recently we showed that proteomic profiling with sequential window acquisition of all theoretical fragment ion spectra (SWATH) mass spectrometry (MS) can identify individuals with pre-diabetes more likely to experience weight change in relation to lifestyle change. We investigated whether baseline proteomic profiles predicted weight change over time using data from the BeneMin clinical trial of the anti-inflammatory antibiotic, minocycline, versus placebo. Expression levels for 844 proteins were determined by

SUBMITTER: Heald A 

PROVIDER: S-EPMC7590460 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature