Potential role of intestinal microflora in disease progression among patients with different stages of Hepatitis B.

ABSTRACT:

Background

Increasing evidence demonstrate that the gut microbiota is involved in the pathogenesis of liver diseases, and faecal microbiota transplantation is considered to be a promising new treatment option. However, there are no reports on the intestinal flora of asymptomatic HBV carriers using next-generation sequencing. This study intends to investigate the potential role of the intestinal microflora in predicting the progression of Hepatitis B patients in different non-cancerous stages.

Results

A total of 266 patients with different stages of Hepatitis B and 31 healthy controls were included in this study. Some of the subjects (217 cases) underwent 16S rRNA gene sequencing. Compared with the control group (CK), the α diversity of patients in Group A (HBV carrier) sligh

SUBMITTER: Yang XA 

PROVIDER: S-EPMC7590496 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature