An integrated autophagy-related gene signature predicts prognosis in human endometrial Cancer.

ABSTRACT:

Background

Globally, endometrial cancer is the fourth most common malignant tumor in women and the number of women being diagnosed is increasing. Tumor progression is strongly related to the cell survival-promoting functions of autophagy. We explored the relationship between endometrial cancer prognoses and the expression of autophagy genes using human autophagy databases.

Methods

The Cancer Genome Atlas was used to identify autophagy related genes (ARGs) that were differentially expressed in endometrial cancer tissue compared to healthy endometrial tissue. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were referenced to identify important biological functions and signaling pathways related to these differentially expressed ARGs. A prognostic model for endometria

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7590615 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature