MazEF-rifampicin interaction suggests a mechanism for rifampicin induced inhibition of persisters.

ABSTRACT:

Background

Persistence is a natural phenomenon whereby a subset of a population of isogenic bacteria either grow slow or become dormant conferring them with the ability to withstand various stresses including antibiotics. In a clinical setting bacterial persistence often leads to the recalcitrance of various infections increasing the treatment time and cost. Additionally, some studies also indicate that persistence can also pave way for the emergence of resistant strains. In a laboratory setting this persistent phenotype is enriched in nutritionally deprived environments. Consequently, in a batch culture the late stationary phase is enriched with persistent bacteria. The mechanism of persister cell formation and its regulation is not well understood. Toxin-antitoxin (TA) systems ha

SUBMITTER: Alexander C 

PROVIDER: S-EPMC7590665 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature