Differential immune cell infiltrations between healthy periodontal and chronic periodontitis tissues.

ABSTRACT:

Background

Host immunity plays an important role against oral microorganisms in periodontitis.

Methods

This study assessed the infiltrating immune cell subtypes in 133 healthy periodontal and 210 chronic periodontitis tissues from Gene Expression Omnibus (GEO) datasets using the CIBERSORT gene signature files.

Results

Plasma cells, naive B cells and neutrophils were all elevated in periodontitis tissues, when compared to those in healthy controls. In contrast, memory B cells, resting dendritic, mast cells and CD4 memory cells, as well as activated mast cells, M1 and M2 macrophages, and follicular helper T cells, were mainly present in healthy periodontal tissues. Furthermore, these periodontitis tissues generally contained a higher proportion of activated CD4 memory T

SUBMITTER: Li W 

PROVIDER: S-EPMC7590666 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature