DjinniChip: evaluation of a novel molecular rapid diagnostic device for the detection of Chlamydia trachomatis in trachoma-endemic areas.

ABSTRACT:

Background

The clinical signs of active trachoma are often present in the absence of ocular Chlamydia trachomatis infection, particularly following mass drug administration. Treatment decisions following impact surveys and in post-control surveillance for communities are currently based on the prevalence of clinical signs, which may result in further unnecessary distribution of mass antibiotic treatment and the increased spread of macrolide resistance alleles in 'off-target' bacterial species. We therefore developed a simple, fast, low cost diagnostic assay (DjinniChip) for diagnosis of ocular C. trachomatis for use by trachoma control programmes.

Methods

The study was conducted in the UK, Germany and Tanzania. For clinical testing in Tanzania, specimens from a sample of 350

SUBMITTER: Derrick TR 

PROVIDER: S-EPMC7590679 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature