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Precision Therapy of Pancreatic Cancer: From Bench to Bedside.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC), with a mortality rate of 94% and a 5-year-survival rate of only 8%, is one of the deadliest cancer entities worldwide, and early diagnostic methods as well as effective therapies are urgently needed.

Summary

This review summarizes current clinical procedure and recent developments of oncological therapy in the palliative setting of metastatic PDAC. It further gives examples of successful, as well as failed, targeted therapy approaches and finally discusses promising ongoing research into the decade-old question of the "undruggability" of KRAS.

Key messages

Bench-driven concepts change the clinical landscape from "one size fits all" towards precision medicine. With growing insight into the molecular mechanisms of pancreatic cancer the era of targeted therapy in PDAC is gaining a new momentum.

SUBMITTER: Ciecielski KJ

PROVIDER: S-EPMC7590788 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Precision Therapy of Pancreatic Cancer: From Bench to Bedside.

Ciecielski Katrin Jana KJ Berninger Alexandra A Algül Hana H

Visceral medicine 20201006 5

<h4>Background</h4>Pancreatic ductal adenocarcinoma (PDAC), with a mortality rate of 94% and a 5-year-survival rate of only 8%, is one of the deadliest cancer entities worldwide, and early diagnostic methods as well as effective therapies are urgently needed.<h4>Summary</h4>This review summarizes current clinical procedure and recent developments of oncological therapy in the palliative setting of metastatic PDAC. It further gives examples of successful, as well as failed, targeted therapy appro ...[more]

PMID: 33178734

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