Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression.

ABSTRACT:

Objectives

Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian cancer, EOC. Our study aimed to address this issue.

Methods

We first examine KBTBD8 expression in EOC tissues and cells. Next, we performed RNA sequencing to reveal the overall mechanism. Then we investigated the roles of KBTBD8 in the proliferation, migration, and health status of cultured EOC cells. Finally, we employed tumor xenograft models to evaluate the role of KBTBD8 in vivo.

Results

First, KBTBD8 level was significantly higher in EOC tissues and cells. Next, comparative RNA sequencing identified more tumorigenesis-related genes that KBTBD8 might

SUBMITTER: Du L 

PROVIDER: S-EPMC7590797 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature