Differences in intrinsic aerobic capacity alters sensitivity to ischemia-reperfusion injury but not cardioprotective capacity by ischemic preconditioning in rats.

ABSTRACT:

Introduction

Aerobic capacity is a strong predictor of cardiovascular mortality. Whether aerobic capacity influences myocardial ischemia and reperfusion (IR) injury is unknown.

Purpose

To investigate the impact of intrinsic differences in aerobic capacity and the cardioprotective potential on IR injury.

Methods

We studied hearts from rats developed by selective breeding for high (HCR) or low (LCR) capacity for treadmill running. The rats were randomized to: (1) control, (2) local ischemic preconditioning (IPC) or (3) remote ischemic preconditioning (RIC) followed by 30 minutes of ischemia and 120 minutes of reperfusion in an isolated perfused heart model. The primary endpoint was infarct size. Secondary endpoints included uptake of labelled glucose, content of selecte

SUBMITTER: Hjortbak MV 

PROVIDER: S-EPMC7591019 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature