Identification of an oral microbiota signature associated with an impaired orosensory perception of lipids in insulin-resistant patients.

ABSTRACT:

Aims

Type 2 diabetes leads to multiple sensory dysfunctions affecting notably the gustatory sensitivity. Although this sensory defect, by impacting food choices, might lead to unhealthy eating behavior, underlying mechanisms remains poorly studied. We have recently reported that the composition of microbiota in contact with circumvallate gustatory papillae might affect the orosensory perception of lipids in lean and normoglycemic obese subjects. This finding has prompted us to explore whether such a phenomenon also occurs in diabetic obese patients.

Methods

The composition of microbiota surrounding the circumvallate papillae was analyzed in combination with the linoleic acid perception thresholds in male insulin-resistant patients and weight-matched healthy controls. Two com

SUBMITTER: Besnard P 

PROVIDER: S-EPMC7591415 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature