The choice of biopolymer is crucial to trigger angiogenesis with vascular endothelial growth factor releasing coatings.

ABSTRACT: Bio-based coatings and release systems for pro-angiogenic growth factors are of interest to overcome insufficient vascularization and bio-integration of implants. This study compares different biopolymer-based coatings on polyethylene terephthalate (PET) membranes in terms of coating homogeneity and stability, coating thickness in the swollen state, endothelial cell adhesion, vascular endothelial growth factor (VEGF) release and pro-angiogenic properties. Coatings consisted of carbodiimide cross-linked gelatin type A (GelA), type B (GelB) or albumin (Alb), and heparin (Hep), or they consisted of radically cross-linked gelatin methacryloyl-acetyl (GM5A5) and heparin methacrylate (HepM5). We prepared films with thicknesses of 8-10 µm and found that all coatings were homogeneous after washing

SUBMITTER: Claaßen C 

PROVIDER: S-EPMC7591429 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature