A Seven Immune-Related lncRNAs Model to Increase the Predicted Value of Lung Adenocarcinoma.

ABSTRACT:

Background

Recent research has shown that immune-related lncRNA plays a crucial part in the tumor immune microenvironment. This study tried to identify immune-related lncRNAs and construct a robust prediction model to increase the predicted value of lung adenocarcinoma (LUAD).

Methods

RNA expression data of LUAD were download from the Cancer Genome Atlas (TCGA) database. Immune genes were acquired from the Molecular Signatures Database (MSigDB). The immune gene related lncRNAs were acquired by the "limma R" package and Cytoscape3.7.1. Cox regression analysis was applied to construct this forecast model. The prognostic model was validated by the testing cohort which was acquired by the bootstrap method.

Results

A total of 551 lncRNA expression profiles including 497 LU

SUBMITTER: Li JP 

PROVIDER: S-EPMC7591457 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature