Pre-sarcopenia determines post-progression outcomes in advanced hepatocellular carcinoma after sorafenib failure.

ABSTRACT: Many second-line therapies are recently approved for patients with advanced hepatocellular carcinoma (HCC), in whom protein malnutrition is prevalent that would affect treatment outcomes. In this study, we aimed to investigate the role of pre-sarcopenia and muscle restoration in patients with sorafenib-failed advanced HCC. From August 2012 to March 2017, 385 patients who developed radiology-proven HCC progression after sorafenib treatment were enrolled in the study. Pre-sarcopenia is defined as transverse psoas muscle thickness per body height < 16.8 mm/m, which was prevalent (64.7%) in our patients. Age > 60 years, female gender, and body mass index < 22 kg/m² were independent predictors to the development of pre-sarcopenia. Patients with muscle depletion had significantly wors

SUBMITTER: Cheng TY 

PROVIDER: S-EPMC7591538 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature