T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting.

ABSTRACT: Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this 'normalises' CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting.

SUBMITTER: Hanley CJ 

PROVIDER: S-EPMC7591574 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature