Differential expression of nuclear genes encoding mitochondrial proteins from urban and rural populations in Morocco.

ABSTRACT: Urbanization in low-income countries represents an important inflection point in the epidemiology of disease, with rural populations experiencing high rates of chronic and recurrent infections and urban populations displaying a profile of noncommunicable diseases. To investigate if urbanization alters the expression of genes encoding mitochondrial proteins, we queried gene microarray data from rural and urban populations living in Morocco (GSE17065). The R Bioconductor packages edgeR and limma were used to identify genes with different expression. The experimental design was modeled upon location and sex. Nuclear genes encoding mitochondrial proteins were identified from the MitoCarta2.0 database. Of the 1158 genes listed in the MitoCarta2.0 database, 847 genes (73%) were available for ana

SUBMITTER: Bickler SW 

PROVIDER: S-EPMC7591688 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature