Elevated Exhaustion Levels of NK and CD8⁺ T Cells as Indicators for Progression and Prognosis of COVID-19 Disease.

ABSTRACT:

Background

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) induced Coronavirus Disease 2019 (COVID-19) has posed a global threat to public health. The immune system is crucial in defending and eliminating the virus and infected cells. However, immune dysregulation may result in the rapid progression of COVID-19. Here, we evaluated the subsets, phenotypic and functional characteristics of natural killer (NK) and T cells in patients with COVID-19 and their associations with disease severity.

Methods

Demographic and clinical data of COVID-19 patients enrolled in Wuhan Union Hospital from February 25 to February 27, 2020, were collected and analyzed. The phenotypic and functional characteristics of NK cells and T cells subsets in circulating blood and serum levels o

SUBMITTER: Li M 

PROVIDER: S-EPMC7591707 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature