A pyrene-based ratiometric fluorescent probe with a large Stokes shift for selective detection of hydrogen peroxide in living cells.

ABSTRACT: Hydrogen peroxide (H₂O₂) plays a significant role in regulating a variety of biological processes. Dysregulation of H₂O₂ can lead to various diseases. Although numerous fluorescent imaging probes for H₂O₂ have been reported, the development of H₂O₂ ratiometric fluorescent probe with large Stokes shift remains rather limited. Such probes have shown distinct advantages, such as minimized interference from environment and improved signal-to noise ratio. In this work, we reported a new pyrene-based compound Py-VPB as H₂O₂ fluorescent probe in vitro. The probe demonstrated ratiometric detection behavior, large Stokes shift and large emission shift. In addition, the probe showed h

SUBMITTER: Chen Q 

PROVIDER: S-EPMC7591780 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature