Genetically Predicted Circulating Level of C-Reactive Protein Is Not Associated With Prostate Cancer Risk.

ABSTRACT:

Background

Inconsistent findings from observational studies have reported that C-reactive protein (CRP) is likely associated with risk of prostate cancer. Because conventional observational studies are susceptible to confounding and reverse causality, it remains unclear whether there is a causal relationship of CRP with risk of prostate cancer.

Methods

In this study, we applied a two-sample Mendelian randomization (MR) approach to evaluate the potential causal association of circulating CRP levels with prostate cancer risk. Instrumental variables (IVs) and corresponding genetic association estimates for circulating CRP levels were obtained from a meta-analysis of genome-wide association studies (GWASs) including 204,402 participants of European descent. The genetic associati

SUBMITTER: He C 

PROVIDER: S-EPMC7591790 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature