Strategies for PET imaging of the receptor for advanced glycation endproducts (RAGE).

ABSTRACT: The implication of the receptor for advanced glycation end-products (RAGE) in numerous diseases and neurodegenerative disorders makes it interesting both as a therapeutic target and as an inflammatory biomarker. In the context of investigating RAGE as a biomarker, there is interest in developing radiotracers that will enable quantification of RAGE using positron emission tomography (PET) imaging. We have synthesized potential small molecule radiotracers for both the intracellular ([¹⁸F]InRAGER) and extracellular ([¹⁸F]RAGER) domains of RAGE. Herein we report preclinical evaluation of both using in vitro (lead panel screens) and in vivo (rodent and nonhuman primate PET imaging) methods. Both radiotracers have high affinity for RAGE and show good brain uptake, but suffe

SUBMITTER: Drake LR 

PROVIDER: S-EPMC7591811 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature