Distributed changes of the functional connectome in patients with glioblastoma.

ABSTRACT: Glioblastoma might have widespread effects on the neural organization and cognitive function, and even focal lesions may be associated with distributed functional alterations. However, functional changes do not necessarily follow obvious anatomical patterns and the current understanding of this interrelation is limited. In this study, we used resting-state functional magnetic resonance imaging to evaluate changes in global functional connectivity patterns in 15 patients with glioblastoma. For six patients we followed longitudinal trajectories of their functional connectome and structural tumour evolution using bi-monthly follow-up scans throughout treatment and disease progression. In all patients, unilateral tumour lesions were associated with inter-hemispherically symmetric network alter

SUBMITTER: Nenning KH 

PROVIDER: S-EPMC7591862 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature