The trans-kingdom battle between donor and recipient gut microbiome influences fecal microbiota transplantation outcome.

ABSTRACT: Fundamental restoration ecology and community ecology theories can help us better understand the underlying mechanisms of fecal microbiota transplantation (FMT) and to better design future microbial therapeutics for recurrent Clostridioides difficile infections (rCDI) and other dysbiosis-related conditions. In this study, stool samples were collected from donors and rCDI patients one week prior to FMT (pre-FMT), as well as from patients one week following FMT (post-FMT). Using metagenomic sequencing and machine learning, our results suggested that FMT outcome is not only dependent on the ecological structure of the recipients, but also the interactions between the donor and recipient microbiomes at the taxonomical and functional levels. We observed that the presence of specific bacteria in

SUBMITTER: Kazemian N 

PROVIDER: S-EPMC7591866 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature