Genetic signatures of high-altitude adaptation and geographic distribution in Tibetan sheep.

ABSTRACT: Most sheep breeding programs designed for the tropics and sub-tropics have to take into account the impacts of environmental adaptive traits. However, the genetic mechanism regulating the multiple biological processes driving adaptive responses remains unclear. In this study, we applied a selective sweep analysis by combing 1% top values of F_st and ZHp on both altitude and geographic subpopulations (APS) in 636 indigenous Tibetan sheep breeds. Results show that 37 genes were identified within overlapped genomic regions regarding F_st significantly associated with APS. Out of the 37 genes, we found that 8, 3 and 6 genes at chromosomes (chr.) 13, 23 and 27, respectively, were identified in the genomic regions with 1% top values of ZHp. We further analyzed the INDEL varia

SUBMITTER: Liu J 

PROVIDER: S-EPMC7591910 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature