Evaluation of an angiotensin Type 1 receptor blocker on the reconsolidation of fear memory.

ABSTRACT: Inhibition of the angiotensin type 1 receptor (AT₁R) has been shown to decrease fear responses in both humans and rodents. These effects are attributed to modulation of extinction learning, however the contribution of AT₁R to alternative memory processes remains unclear. Using classic Pavlovian conditioning combined with radiotelemetry and whole-genome RNA sequencing, we evaluated the effects of the AT₁R antagonist losartan on fear memory reconsolidation. Following the retrieval of conditioned auditory fear memory, animals were given a single intraperitoneal injection of losartan or saline. In response to the conditioned stimulus (CS), losartan-treated animals exhibited significantly less freezing at 24 h and 1 week; an effect that was dependent upon memory

SUBMITTER: Swiercz AP 

PROVIDER: S-EPMC7591922 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature