LncRNA CASC2 Enhances ¹³¹I Sensitivity in Papillary Thyroid Cancer by Sponging miR-155.

ABSTRACT: Long noncoding RNA cancer susceptibility candidate 2 (CASC2) has been reported to play an anticancer role in papillary thyroid cancer (PTC). Radioiodine (¹³¹I) is a common option for the treatment of PTC. However, the role and mechanism of CASC2 in ¹³¹I sensitivity remain unclear. In this study, ¹³¹I-resistant cells were constructed through continuous treatment of ¹³¹I. The expression levels of CASC2 and miR-155 were measured by qRT-PCR. The IC50 of ¹³¹I was analyzed by cell viability using MTT assay. Flow cytometry was conducted to determine cell apoptosis induced by ¹³¹I. The association between CASC2 and miR-155 was evaluated by luciferase assay and RNA immunoprecipitation. A mouse xenograft model was built to explore the

SUBMITTER: Tao L 

PROVIDER: S-EPMC7591961 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature