Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration.

ABSTRACT:

Background

Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.

Methods

Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.

Results

For all subsites, cancer risk steeply increased with increasing drinks/day, wit

SUBMITTER: Di Credico G 

PROVIDER: S-EPMC7592048 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature