Reliability of quantitative transverse relaxation time mapping with [Formula: see text]-prepared whole brain pCASL.

ABSTRACT: Arterial spin labeling (ASL) is increasingly applied for cerebral blood flow mapping, but [Formula: see text] relaxation of the ASL signal magnetization is often ignored, although it may be clinically relevant. To investigate the extent, to which quantitative [Formula: see text] values in gray matter (GM) obtained by pseudocontinuous ASL (pCASL) perfusion MRI can be reproduced, are reliable and a potential neuroscientific biomarker, a prospective study was performed with ten healthy volunteers (5F,28 ± 3y) at a 3 T scanner. A [Formula: see text]-prepared pCASL sequence enabled the measurement of quantitative [Formula: see text] and perfusion maps. [Formula: see text] times were modeled per voxel and analyzed within four GM-regions-of-interest (ROI). The intraclass correlation coefficients

SUBMITTER: Schidlowski M 

PROVIDER: S-EPMC7592060 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature