Outcomes after Pancreatectomy with Routine Pasireotide Use.

ABSTRACT:

Background

Morbidity after pancreatectomy is commonly due to leakage of exocrine secretions resulting in abscess or pancreatic fistula (PF). Previously, we authored a double-blind randomized controlled trial demonstrating that perioperative pasireotide administration lowers abscess or PF formation by >50%. Accordingly, we adopted pasireotide use as standard practice after pancreatectomy in October 2014 and hypothesized a similar PF/abscess rate reduction would be observed.

Study design

A prospectively maintained database was queried for all patients who underwent pancreatectomy between October 2014 and July 2017. Pasireotide was administered preoperatively and twice daily for 7 days postoperatively or until discharge. The primary end point was clinically relevant PF/abscess

SUBMITTER: Kunstman JW 

PROVIDER: S-EPMC7592191 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature