Development of a Fluorescence-Based, High-Throughput SARS-CoV-2 3CLpro Reporter Assay.

ABSTRACT: In late 2019, a human coronavirus, now known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged, likely from a zoonotic reservoir. This virus causes COVID-19, has infected millions of people, and has led to hundreds of thousands of deaths across the globe. While the best interventions to control and ultimately stop the pandemic are prophylactic vaccines, antiviral therapeutics are important to limit morbidity and mortality in those already infected. At this time, only one FDA-approved anti-SARS-CoV-2 antiviral drug, remdesivir, is available, and unfortunately, its efficacy appears to be limited. Thus, the identification of new and efficacious antivirals is of the highest importance. In order to facilitate rapid drug discovery, flexible, sensitive, and high-throughput

SUBMITTER: Froggatt HM 

PROVIDER: S-EPMC7592234 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature