Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma.

ABSTRACT:

Background

Despite some successes with checkpoint inhibitors for treating cancer, most patients remain refractory to treatment, possibly due to the inhibitory nature of the tumor stroma that impedes the function and entry of effector cells. We devised a new technique of combining immunotherapy with radiotherapy (XRT), more specifically low-dose XRT, to overcome the stroma and maximize systemic outcomes.

Methods

We bilaterally established 344SQ lung adenocarcinoma tumors in 129Sv/Ev mice. Primary and secondary tumors were irradiated with either high-dose or low-dose of XRT with systemic anti-programmed cell death protein 1 and anti-cytotoxic T-lymphocyte associated protein 4 administration. Survival and tumor growth were monitored for the various groups, and secondary tumors

SUBMITTER: Barsoumian HB 

PROVIDER: S-EPMC7592253 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature