Randomised trial of azithromycin to eradicate Ureaplasma in preterm infants.

ABSTRACT:

Objective

To test whether azithromycin eradicates Ureaplasma from the respiratory tract in preterm infants.

Design

Prospective, phase IIb randomised, double-blind, placebo-controlled trial.

Setting

Seven level III-IV US, academic, neonatal intensive care units (NICUs).

Patients

Infants 24⁰-28⁶ weeks' gestation (stratified 24⁰-26⁶; 27⁰-28⁶ weeks) randomly assigned within 4 days following birth from July 2013 to August 2016.

Interventions

Intravenous azithromycin 20 mg/kg or an equal volume of D5W (placebo) every 24 hours for 3 days.

Main outcome measures

The primary efficacy outcome was Ureaplasma-free survival. Secondary outcomes were all-cause mortality, Ureaplasma

SUBMITTER: Viscardi RM 

PROVIDER: S-EPMC7592356 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature