The oral microbiome and salivary proteins influence caries in children aged 6 to 8 years.

ABSTRACT:

Background

Oral microbiome and salivary proteins play a critical role in the occurrence and development of caries. In this study, we used metagenomic and metaproteomic analyses to explore the microbiological and proteinic biomarkers and investigate the etiology of caries in 6-8 years old children. Our study aims to offer a better comprehension of these factors and the relationship with caries, and these findings might facilitate caries risk assessment and provide a basis for future prevention strategies.

Methods

Children 6 to 8 years old living in rural isolated areas including 40 caries-active subjects and 40 caries-free subjects were recruited. Supragingival plaque and unstimulated saliva were collected for 16S rDNA pyrosequencing and isobaric tags for relative and absolut

SUBMITTER: Chen W 

PROVIDER: S-EPMC7592381 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature