Microbial signature in IgE-mediated food allergies.

ABSTRACT:

Background

Multiple studies suggest a key role for gut microbiota in IgE-mediated food allergy (FA) development, but to date, none has studied it in the persistent state.

Methods

To characterize the gut microbiota composition and short-chain fatty acid (SCFAs) profiles associated with major food allergy groups, we recruited 233 patients with FA including milk (N = 66), sesame (N = 38), peanut (N = 71), and tree nuts (N = 58), and non-allergic controls (N = 58). DNA was isolated from fecal samples, and 16S rRNA gene sequences were analyzed. SCFAs in stool were analyzed from patients with a single allergy (N = 84) and controls (N = 31).

Results

The gut microbiota composition of allergic patients was significantly different compared to age-matched controls both in α-dive

SUBMITTER: Goldberg MR 

PROVIDER: S-EPMC7592384 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature