Textural analysis and lung function study: Predicting lung fitness for radiotherapy from a CT scan.

ABSTRACT:

Objective

This study tested the hypothesis that shows advanced image analysis can differentiate fit and unfit patients for radical radiotherapy from standard radiotherapy planning imaging, when compared to formal lung function tests, FEV1 (forced expiratory volume in 1 s) and TLCO (transfer factor of carbon monoxide).

Methods

An apical region of interest (ROI) of lung parenchyma was extracted from a standard radiotherapy planning CT scan. Software using a grey level co-occurrence matrix (GLCM) assigned an entropy score to each voxel, based on its similarity to the voxels around it.

Results

Density and entropy scores were compared between a cohort of 29 fit patients (defined as FEV1 and TLCO above 50 % predicted value) and 32 unfit patients (FEV1 or TLCO below 50% pred

SUBMITTER: Phillips I 

PROVIDER: S-EPMC7592404 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature