Impact of Radiation Therapy Dose Escalation on Prostate Cancer Outcomes and Toxicities.

ABSTRACT:

Objectives

Freedom from biochemical failure (FFBF) is a common primary outcome of randomized-controlled trials of prostate cancer (PCa). We aimed to determine how increasing the PCa biologically equivalent dose (BED) of external radiation therapy (RT) is correlated with FFBF and overall patient outcomes: overall survival (OS), distant metastasis (DM), and cancer-specific mortality (CSM); as well as genitourinary (GU), and gastrointestinal toxicities.

Materials and methods

We performed a meta-analysis of 6884 PCa patients from 12 randomized-controlled trials of external beam RT. Mixed effects regression models were used to estimate weighted linear relationships between BED and observed percentages of 5- and 10-year outcomes. For toxicities, a subset analysis of using 3-dimens

SUBMITTER: Zaorsky NG 

PROVIDER: S-EPMC7592421 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature