Ontology highlight
ABSTRACT:
SUBMITTER: Costa GC
PROVIDER: S-EPMC7592494 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Memorias do Instituto Oswaldo Cruz 20201028
We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showed a more activated profile upon in vitro infection with T. cruzi than CD14+ ...[more]