Selecting a Scale for Spatial Confounding Adjustment.

ABSTRACT: Unmeasured, spatially-structured factors can confound associations between spatial environmental exposures and health outcomes. Adding flexible splines to a regression model is a simple approach for spatial confounding adjustment, but the spline degrees of freedom do not provide an easily interpretable spatial scale. We describe a method for quantifying the extent of spatial confounding adjustment in terms of the Euclidean distance at which variation is removed. We develop this approach for confounding adjustment with splines and using Fourier and wavelet filtering. We demonstrate differences in the spatial scales these bases can represent and provide a comparison of methods for selecting the amount of confounding adjustment. We find the best performance for selecting the amount of adjustm

SUBMITTER: Keller JP 

PROVIDER: S-EPMC7592711 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature