Gut microbiota profiles of treatment-naive adult acute myeloid leukemia patients with neutropenic fever during intensive chemotherapy.

ABSTRACT: The intestinal bacterial flora of febrile neutropenic patients has been found to be significantly diverse. However, there are few reports of alterations of in adult acute myeloid leukemia (AML) patients. Stool samples of each treatment-naïve AML patient were collected the day before initiation of induction chemotherapy (pretreatment), on the first date of neutropenic fever and first date of bone marrow recovery. Bacterial DNA was extracted from stool samples and bacterial 16s ribosomal RNA genes were sequenced by next-generation sequencing. Relative abundance, overall richness, Shannon's diversity index and Simpson's diversity index were calculated. No antimicrobial prophylaxis was in placed in all participants. Ten cases of AML patients (4 male and 6 female) were included with a median ag

SUBMITTER: Rattanathammethee T 

PROVIDER: S-EPMC7592783 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature