Alignment of Alzheimer's Disease Amyloid-β Peptide and Herpes Simplex Virus-1 pUL15 C-Terminal Nuclease Domain.

ABSTRACT:

Background

The cause of Alzheimer's disease (AD) is poorly understood. Neurotropic microbes, particularly herpesviruses, might set off chronic neuroinflammation. Amyloid-β (Aβ) has antimicrobial properties and could represent a brain defense against infection.

Objective

We searched for protein sequence alignment between herpes simplex virus type I (HSV-1) HSV-2, and Aβ.

Methods

Protein data bank (pdb) structures for Aβ, HSV-1, and HSV-2 were searched on the RCSB Protein Data Bank. The protein structures were superimposed and aligned on PYMOL v 2.3.4.

Results

For HSV-1 and Aβ, amino acid residues ser549 - his569 of HSV-1 aligned closely with residues asp7 - asn27 of Aβ. For HSV-2 and Aβ, amino acid residues of HSV-2 aligned less closely than those of HSV-1 with

SUBMITTER: Lehrer S 

PROVIDER: S-EPMC7592838 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature