Analysis of Innate and Adaptive Immunological Characteristics in Patients with IgG4-Related Disease.

ABSTRACT:

Background

Immunoglobulin G4-related disease (IgG4-RD) is a systemic immunological disorder characterized by fibro-inflammatory conditions; however, the pathobiology of IgG4-RD has not been fully identified.

Objective

This study aimed to analyze systemic differences of innate and adaptive immune cells from healthy controls and patients with IgG4-RD.

Methods

Healthy controls (n = 9) and IgG4-RD patients (n = 7) were recruited with informed consent. Peripheral blood was collected from healthy controls and IgG4-RD patients, and three blood samples from IgG4-RD patients were re-collected two months after the last rituximab (RTX) treatment. The various immune cells and cytokine productions were measured by flow cytometry.

Results

Blood CD14+ monocytes and steady-sta

SUBMITTER: Sohn KH 

PROVIDER: S-EPMC7592937 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature