Regenerative effect of mesenteric fat stem cells on ccl4-induced liver cirrhosis, an experimental study.

ABSTRACT:

Background

Liver cirrhosis is a chronic disease in which normal liver tissue is replaced by fibrous tissue, leads to liver malfunction. Although transplantation is the most certain cure, stem cell therapies are shedding light on efforts to regenerate cirrhotic liver. The purpose of this study was to evaluate the regenerative potential of mesenteric fat stem cells in CCL4-induced liver cirrhosis in an animal model.

Methods

Thirty rats were treated with the mixture of CCL4 and olive oil intraperitoneally by a dose of 0.2 ml (0.1 ml CCL4 and 0.1 ml olive oil) every other day for 16 weeks till cirrhosis signs appeared. Fifteen rats were randomly selected as control group. Others treated by mesenteric fat derived mesenchymal stem cells transferred into the liver parenchyma.

Re

SUBMITTER: Nazhvani FD 

PROVIDER: S-EPMC7593263 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature