Development and validation of an immune-related gene prognostic model for stomach adenocarcinoma.

ABSTRACT:

Purpose

Stomach adenocarcinoma (STAD) is one of the most common malignant tumors, and its occurrence and prognosis are closely related to inflammation. The aim of the present study was to identify gene signatures and construct an immune-related gene (IRG) prognostic model in STAD using bioinformatics analysis.

Methods

RNA sequencing data from healthy samples and samples with STAD, IRGs, and transcription factors were analyzed. The hub IRGs were identified using univariate and multivariate Cox regression analyses. Using the hub IRGs, we constructed an IRG prognostic model. The relationships between IRG prognostic models and clinical data were tested.

Results

A total of 289 differentially expressed IRGs and 20 prognostic IRGs were screened with a threshold of P<0.05. Th

SUBMITTER: Wu M 

PROVIDER: S-EPMC7593539 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature