Glabridin Attenuates the Retinal Degeneration Induced by Sodium Iodate In Vitro and In Vivo.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is one of the major causes of blindness in the elderly over the age of 60. AMD is divided into dry AMD and wet AMD. Although there are certain treatment methods for wet age-related macular degeneration (AMD), there are no effective treatments for dry AMD yet, and finding new drugs or treatment methods for dry AMD has become a priority. For this purpose, this study explored Glabridin (Glab), an isoflavane found in the root extract of licorice, which has never been investigated in relation to eye diseases.

Purpose

To investigate the effect of Glab on the sodium iodate (NaIO₃) induced retinal degeneration in vitro and in vivo.

Methods

In vitro, cell viability and cytotoxicity were tested wi

SUBMITTER: Aung KH 

PROVIDER: S-EPMC7593553 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature