Methodological considerations for a better somatosensory gating paradigm: The impact of the inter-stimulus interval.

ABSTRACT: Sensory gating (SG) is a neurophysiological phenomenon whereby the response to the second stimulus in a repetitive pair is attenuated. This filtering of irrelevant or redundant information is thought to preserve neural resources for more behaviorally-relevant stimuli and thereby reflect the functional inhibition of sensory input. Developing a SG paradigm in which optimal suppression of sensory input is achieved requires investigators to consider numerous parameters such as stimulus intensity, time between stimulus pairs, and the inter-stimulus interval (ISI) within each pair. While these factors have been well defined for the interrogation of auditory gating, the precise parameters for eliciting optimal gating in the somatosensory domain are far less understood. To address this, we investi

SUBMITTER: Spooner RK 

PROVIDER: S-EPMC7593607 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature