Epidemiology of autosomal-dominant polycystic liver disease in Olmsted county.

ABSTRACT:

Background & aims

Isolated autosomal-dominant polycystic liver disease (ADPLD) is generally considered a rare disease. However, the frequency of truncating mutations to ADPLD genes in large, population sequencing databases is 1:496. With the increasing use of abdominal imaging, incidental detection of hepatic cysts and ADPLD has become more frequent. The present study was performed to ascertain the incidence and point prevalence of ADPLD in Olmsted County, MN, USA, and how these are impacted by the increasing utilisation of abdominal imaging.

Methods

The Rochester Epidemiology Project and radiology databases of Mayo Clinic and Olmsted Medical Center were searched to identify all subjects meeting diagnostic criteria for definite, likely, or possible ADPLD. Annual incidence ra

SUBMITTER: Suwabe T 

PROVIDER: S-EPMC7593615 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature